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Information
| Code | DM0016 |
| Name | Epigenetic Dynamics of Stem Cell |
| Term | 2023-2024 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
Regulation of stem cells by epigenetic mechanisms, Reprogramming and changes in chromatin level, self-renewal, To know the differentiation mechanisms
Course Content
Stem cell potential and epigenetic regulation
Course Precondition
None
Resources
Lecture Notes
Notes
Stem cells (Biology, Types and Uses in Treatment) Alp CAN
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Embryo fibroblasts and cytokines will be learned. |
| LO02 | The life cycle of stem cells, stress and aging will be learned. |
| LO03 | Embryonic stem cells will be learned. |
| LO04 | Embryo and fetus-derived multipotent stem cells will be learned. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Yetkinlikler - Alana Özgü Yetkinlik | Having advanced knowledge of the concepts, theories and principles of the Tissue Engineering Department | 4 |
| PLO02 | Yetkinlikler - Alana Özgü Yetkinlik | Being equipped with advanced mathematics, science and engineering knowledge | |
| PLO03 | Yetkinlikler - Alana Özgü Yetkinlik | To be able to design and perform advanced experiments in the Tissue Engineering Department; To be able to analyze and interpret the results and the data obtained. | 3 |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | Be equipped with a variety of advanced engineering techniques and skills | |
| PLO05 | Yetkinlikler - Alana Özgü Yetkinlik | Ability to lead the definition, design, development and deployment of a product or production method | 3 |
| PLO06 | Yetkinlikler - Alana Özgü Yetkinlik | Being aware of the necessity of lifelong learning and being able to constantly renew oneself | |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | Ability to use English effectively both verbally and in writing on technical or non-technical subjects | |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Being prone to teamwork, being able to communicate well with the environment; Ability to work efficiently as a member of a multi-faceted and interdisciplinary team | 4 |
| PLO09 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Being curious and innovative, aware of its technical and ethical responsibilities | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Gains high-level skills in using research methods in studies related to the field of Tissue Engineering. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Embryo fibroblasts and cytokines | Immune system preliminary research | Öğretim Yöntemleri: Anlatım, Tartışma |
| 2 | Some signaling pathways in stem cells: Wnt, Oct4, Sox2, Nanog | Regulatory molecules | Öğretim Yöntemleri: Anlatım, Tartışma |
| 3 | Epigenetic control of self-renewal and differentiation | Epigenetic fundamentals | Öğretim Yöntemleri: Anlatım |
| 4 | Stem cell life cycle, stress and aging | Cell cycle dynamics | Öğretim Yöntemleri: Anlatım |
| 5 | Preservation of stem cell genome integrity and stress | Regulatory mechanisms | Öğretim Yöntemleri: Anlatım |
| 6 | Reactive oxygen species, telomere protection | Oxidative stress | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap |
| 7 | DNA damage responses and stem cell aging | Epigenetic modifications | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Subject repetition | Ölçme Yöntemleri: Ödev |
| 9 | Embryonic stem cells | Prenatal stages | Öğretim Yöntemleri: Anlatım, Tartışma |
| 10 | Primitive sex cell derivatives | Embryonic differentiations | Öğretim Yöntemleri: Anlatım, Tartışma |
| 11 | Induced pluripotent stem cells | Pluripotency | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Programming factors | Informative molecules | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 13 | The mutation load and tumor-forming ability of the stem cell | Cell cycle control | Öğretim Yöntemleri: Anlatım |
| 14 | Embryo and fetus derived multipotent stem cells | Stem cell sources | Öğretim Yöntemleri: Anlatım |
| 15 | Adult stem cells | Tumor suppression and oncogenesis | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Beyin Fırtınası |
| 16 | Term Exams | Subject repetition | Ölçme Yöntemleri: Sözlü Sınav, Ödev |
| 17 | Term Exams | Final preparation | Ölçme Yöntemleri: Ödev, Sözlü Sınav, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 7 | 98 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 5 | 5 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 5 | 5 |
| Final Exam | 1 | 5 | 5 |
| Total Workload (Hour) | 155 | ||
| Total Workload / 25 (h) | 6,20 | ||
| ECTS | 6 ECTS | ||