TÜRKÇE
ENGLISH
Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOTECHNOLOGY (MASTER) (WITH THESIS) (INTERDISCIPLINARY) | |
| Code | BT023 |
| Name | Biochemical Toxicology in Model Organisms |
| Term | 2024-2025 Academic Year |
| Term | Fall |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. PETEK PİNER BENLİ |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
The aim of this course is to teach students acute and chronic toxicity test in model animals, metabolism of toxic substences, effects of toxic substencens on biochemical processes, the biochemical and molecular markers used in toxicological studies, teratogenesis, genotoxicity and carcinogenesis, biochemical and molecular markers used in toxicity studies
Course Content
Introduction to biochemical toxicology in model animals, Dose-response relationships, Absorption, distribution, metabolism and excretion of toxic compounds, Factors affecting metabolism toxic compunds, Toxic response to foreign compounds, Teratogenesis, Genotoxicity and chemical carcinogenesis, Hepatotoxicity, Kidney damage, Lung damage, Neurotoxicity. Biochemical and molecular markers in toxicity Toxicogenomics, toxicoproteomics, toxicometabolomics
Course Precondition
None
Resources
Principles of Biochemical Toxicology Jhon A Timbrel 2008 M
Notes
olecular and Biochemical Toxicology Robert C. Smart Ernest Hodgson 2018
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explain the dose-response relationship in toxic compounds, the absorption and distribution of toxic compounds, and their excretion. |
| LO02 | Explains metabolism of toxic compounds; Phase 1-2 Biotransformation Reactions. |
| LO03 | List the factors affecting the metabolism of toxic compounds. |
| LO04 | Explains biochemical responses to toxic compounds in their own words. |
| LO05 | Explains model organisms used in biochemical toxicology research and related studies with examples. |
| LO06 | Designs acute and chronic toxicity test designs in biochemical toxicology research. |
| LO07 | Explains the molecular and biochemical basis of teratogenic, carcinogenic and mutagenic effects of toxic compounds in model organisms with their own words. |
| LO08 | Express the biochemical and molecular markers and methods used in toxicity studies. |
| LO09 | Give examples of toxicogenomics, toxicoproteomics, and toxic metabolomics studies. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on undergraduate level qualifications, they develop their knowledge at the level of expertise in the same or a different field. | 2 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Knows the ethical rules to be considered while obtaining biotechnological products. | 1 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 1 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO06 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | |
| PLO07 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | 3 |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to biochemical toxicology in model organisims | There is no preliminary preparation | Öğretim Yöntemleri: Anlatım |
| 2 | Dose- response relationship, Measurement of dose-response relationships | Reading textbook,researching on the internet | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Absorption and distibution of toxic compounds | Researching on the internet, reviewing of visual data | Öğretim Yöntemleri: Anlatım, Tartışma |
| 4 | Metabolism of toxic compounds: Phase-1 Biotransformation Reactions | Reading textbook, review lecture slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Metabolism of toxic compounds: Phase-2 Biotransformation Reactions | Reading textbook, review lecture slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Excretion of toxic compunds | Researching on the internet, reviewing of visual data | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Factors affecting metabolism toxic compunds; Chemical factors, Biological factors | researching on the internet | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Exam preparation | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 9 | Biochemical response toxic compounds | Researching on the internet, doing assignment | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Aquatic animal model for biochemical toxicity tests | Reading textbooks, review lecture slides, researching on the internet | Öğretim Yöntemleri: Anlatım, Tartışma |
| 11 | Mammalian model for biochemical toxicity tests | Reading textbooks, review lecture slides, researching on the internet | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Gösteri |
| 12 | Teratogenic, carcinogenic, mutagenic effects of tocix coumpounds | Researching on the internet, doing assignment | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Hepatotoxicty, Neurotoxicity | Researching on the internet, doing assignment | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Anlatım |
| 14 | Biochemical and molecular marker used in toxicological research | Reading lecture notes, reading textbooks, review lecture slides, researching on the internet, doing assignment | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 15 | Toxicogenomics, toxicoproteomics, toxicometabolomics | Reading textbooks, review lecture slides, researching on the internet | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Exam preparation | Ölçme Yöntemleri: Ödev |
| 17 | Term Exams | Exam preparation | Ölçme Yöntemleri: Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||