TÜRKÇE
ENGLISH
Information
| Code | BT0086 |
| Name | Advanced Protein Biochemistry |
| Term | 2024-2025 Academic Year |
| Term | Spring |
| Duration (T+A) | 2-2 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Prof. Dr. GÜLÜZAR ATLI
(A Group)
(Ins. in Charge)
Prof. Dr. ŞULE SULTAN MENZİLETOĞLU YILDIZ (A Group) (Asst. Ins.) |
Course Goal / Objective
It is aimed to have information about protein synthesis, transcription, translation, proteomics, catabolic processes related to proteins, metabolism of nitrogenous compounds, biochemical principles of metabolic pathways and excretion from the body, electrophoretic and chromatographic techniques, molecular weight determination methods, quantification of specific proteins.
Course Content
Protein synthesis, transcription, translation, proteomics, catabolic processes related to proteins, classification of amino acids according to degradation products, metabolism of non-protein nitrogenous compounds, formation processes of nitrogenous compounds such as ammonia, creatine, urea and nucleotides, function in metabolic pathways and excretion from the body. principles, electrophoretic separation methods, molecular weight determination methods, purification processes with chromatographic techniques, specific protein level measurement analysis.
Course Precondition
None
Resources
Lehninger Principles of Biochemistry (David L. Nelson, Michael Cox)
Notes
Lecture notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explains the mechanisms related to the synthesis of proteins. |
| LO02 | Comments on catabolic processes related to proteins. |
| LO03 | Explains the mechanisms related to the metabolism of nitrogenous compounds. |
| LO04 | Comprehends the biochemical mechanisms involved in the excretion of nitrogenous compounds from the body. |
| LO05 | Have practical knowledge about electrophoresis and chromatography techniques. |
| LO06 | Gains sufficient knowledge about electrophoresis and chromatography techniques and develops this knowledge. |
| LO07 | Comprehends various methods of specific protein and enzyme level measurements. |
| LO08 | Gains the ability to apply various biomarker measurement techniques. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develop and deepen the current and advanced knowledge in the field with original thought and / or research at the level of expertise based on the qualifications of the graduate and reach the original definitions that will bring innovation to the field. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interdisciplinary interaction of the field; it achieves original results using knowledge requiring expertise in analysis, synthesis and evaluation of new and complex ideas. | 4 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Evaluates, uses and transfers new information in the field with a systematic approach. | 3 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | 4 |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Makes leadership in environments that require the analysis of original and interdisciplinary problems. | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It extends the limits of knowledge in its field by publishing at least one scientific article in its field in national and / or international refereed journals and / or producing or interpreting an original work. | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | 3 |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO09 | Yetkinlikler - Alana Özgü Yetkinlik | Conducts scientific research in national and international scientific research groups. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision making processes in solving problems encountered in the field. | 4 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Course content, presentation of various books and literature to be examined | Note preparation regarding course contents | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Protein synthesis | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Gösteri, Tartışma |
| 3 | Structure and conformation of protein molecules | Preparation and summarization of articles on the subject | Öğretim Yöntemleri: Anlatım, Tartışma |
| 4 | Protein classification according to their structures | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Transciption and translation | Preparation of visual slides and related articles on the subject | Öğretim Yöntemleri: Tartışma, Soru-Cevap |
| 6 | Proteomic | Researching and making notes of current publications on the subject | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Catabolic process about proteins | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 8 | Mid-Term Exam | Preparation of homework and questions | Ölçme Yöntemleri: Ödev, Sözlü Sınav |
| 9 | Amino acid classification based on their degradation products | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Gösteri |
| 10 | Metabolism of non-protein nitrogenous compounds | Summary of book chapters on the subject | Öğretim Yöntemleri: Anlatım |
| 11 | Formation processes of nitrogenous compounds such as ammonia, creatine, urea and nucleotides | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Tartışma |
| 12 | Functions of nitrogenous compounds in metabolic pathways | Preparing article summaries on the subject | Öğretim Yöntemleri: Tartışma, Beyin Fırtınası |
| 13 | Biochemical mechanisms related to the excretion of nitrogenous compounds from the body | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Tartışma |
| 14 | Electrophoretic separation techniques | Preparation of relevant chemicals and materials | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 15 | Purification processes of proteins | Preparation of relevant chemicals and materials | Öğretim Yöntemleri: Alıştırma ve Uygulama, Gösterip Yaptırma |
| 16 | Term Exams | Preparation of questions | Ölçme Yöntemleri: Sözlü Sınav, Performans Değerlendirmesi |
| 17 | Term Exams | Preparation of questions | Ölçme Yöntemleri: Sözlü Sınav, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 2 | 2 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 28 | 28 |
| Total Workload (Hour) | 154 | ||
| Total Workload / 25 (h) | 6,16 | ||
| ECTS | 6 ECTS | ||