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Information
| Code | BTE0050 |
| Name | Pharmacogenetics and Biotechnology |
| Term | 2024-2025 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Belirsiz |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. NACİYE DÖNDAŞ |
| Course Instructor |
1 |
Course Goal / Objective
Within the scope of this course, the definition of pharmacogenetics, the importance of biotechnology in pharmacogenetic studies, pharmacogenetic tests, the importance of pharmacogenetics in personalized drug therapy, the use of biotechnology in individual drug development, the elucidation of the structure-activity relationship by creating point mutations with recombinant DNA techniques, the teaching of strategies related to gene therapy and pharmacogenetic analysis. is intended.
Course Content
What is pharmacogenetics, introduction to pharmacogenetics, importance of biotechnology in pharmacogenetic studies, pharmacogenetic tests, importance of pharmacogenetics in personalized drug therapy, biotechnology in pharmacogenetic studies, changes in drug pharmacokinetics due to genetic factors, changes in drug pharmacodynamics due to genetic factors, genetic changes in drug interactions, pharmacogenetics and new drug development , pharmacogenetics and biotechnology in clinical applications, use of biotechnology in the development of individualized drugs, elucidation of the structure-activity relationship by creating point mutations with recombinant DNA techniques, gene therapy and pharmacogenetic analysis.
Course Precondition
No Prerequisites
Resources
1. Erika Cecchin and Gabriele Stocco (Eds.). Pharmacogenomics and Personalized Medicine. ISBN 978-3-03936-730-6 (Hbk); ISBN 978-3-03936-731-3 (PDF), https://doi.org/10.3390/books978-3-03936-731-3, 2020 by the authors; CC BY licence 2. David Flockhart, David B. Goldstein. Principles of Pharmacogenetics and Pharmacogenomics. June 2012, ISBN:9781139051194, Cambridge University Press
Notes
Scientific database
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | The student knows and explains the importance of biotechnology in pharmacogenetic studies. |
| LO02 | Knows and explains the changes in drug pharmacokinetics and pharmacodynamics due to genetic factors. |
| LO03 | Tells the use of biotechnology in the development of individualized drugs. |
| LO04 | Knows and tells gene therapy and pharmacogenetic analysis. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | 3 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 3 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | 3 |
| PLO04 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | 3 |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | 3 |
| PLO06 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | 4 |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology | |
| PLO08 | Bilgi - Kuramsal, Olgusal | Knows the ethical rules to be considered while obtaining biotechnological products. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | 5 |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Gains the ability to develop and deepen their knowledge in the field of biotechnology at the level of expertise. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | What is pharmacogenetics, introduction to pharmacogenetics | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Importance of biotechnology in pharmacogenetic studies | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Pharmacogenetic tests, the importance of pharmacogenetics in personalized drug therapy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Biotechnology in pharmacogenetic studies | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Changes in drug pharmacokinetics due to genetic factors | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Changes in drug pharmacodynamics due to genetic factors | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Genetic variation of drug interaction | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Pharmacogenetics and new drug development | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 9 | Pharmacogenetics and biotechnology in clinical applications | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | The use of biotechnology in the development of individualized drugs. | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Clarifying the structure-activity relationship by creating point mutations with recombinant DNA techniques-1 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Clarifying the structure-activity relationship by creating point mutations with recombinant DNA techniques-2 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Gene therapy-1 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Gene therapy-2 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Pharmacogenetic analyzes | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Midterm exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 17 | Semester final exam | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||