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Information
| Code | EFR503 |
| Name | Signal Tranduction Mechanisms and Neurotransmitters |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Prof. Dr. NURAN ÖĞÜLENER
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
It is aimed to explain and interpret the concept of receptor, definition of receptor types, post-receptor events, signal transducing systems, neurotransmitters, the effects of neurotransmitters and their mechanisms of action.
Course Content
Neurotransmitters, receptor concept, receptor types, post-receptor events and signal transducing mechanisms, molecular level mechanisms of drug action
Course Precondition
None
Resources
Basic & Clinical Pharmacology, McGraw-Hill Medical Books, 2018 Goodman and Gilman's The Pharmacologi-cal Basis of Therapeutics-13 th Edition, McGraw-Hill Medical Books, 2018
Notes
Katzung. Basic of Pharmacology
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Defines the receptor description. |
| LO02 | Classify the receptor types. |
| LO03 | Clasify to G-protein-coupled-receptors |
| LO04 | Explains receptors that show intrinsic kinase activity and receptors associated with extrinsic kinases. |
| LO05 | Explains ligand-operated ion channel type receptors. |
| LO06 | Explain the cell signal transmission mechanisms and the molecules in this mechanism. |
| LO07 | Defines the components of the signal transducing system. |
| LO08 | Explain the subtypes of G-proteins and the effector macromolecules. |
| LO09 | Explain the mechanisms of the second messengers in the formation of the cellular response. |
| LO10 | Explain the concept of neurotransmitter, neurotransmitters and their receptors. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Explain the mechanisms of action of drugs, their pharmacokinetic and pharmacodynamic effects. | 5 |
| PLO02 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Acts in accordance with ethical and legal principles in the field of pharmacology. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Can project and conduct research in the field of pharmacology and analyze and interpret data. | |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | It plays an active role in rational drug use and provides counseling to the patient for the correct use of the drug. | |
| PLO05 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Can convey the current developments or studies in the field of pharmacology verbally or in writing. | 3 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Follows scientific literature and current developments in the field of pharmacology. | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Establishes a relationship between the effects, mechanisms of action and drug interactions of drugs. | 4 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Explain the physiopathology of various diseases and evalue the drugs used in the treatment of these diseases. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Knows and uses good laboratory practices. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Uses the theoretical and applied knowledge gained in the field of pharmacology. | 3 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have the ability to take part in in vitro/in vivo animal studies. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım |
| 2 | Receptor and Drug-Receptor Relationship | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 3 | G-Protein Coupled Receptors | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Receptors Exhibiting Intrinsic Kinase Activity And Receptors Associated With Extrinsic Kinases | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Nuclear Receptors | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 6 | Ligand Operated Ion Channel Receptors | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 7 | Signal Transduction System: Effector Macromolecules and Second Messengers | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Preparing a presentation | Ölçme Yöntemleri: Ödev |
| 9 | Protein kinase A and Protein kinase C pathways | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 10 | Molecular Pharmacology of Protein Kinases | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Cytokine Receptors and JAK-STAT Signaling | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 12 | TOR Signaling | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Insulin/Insulin-Like Growth Factor 1 Signaling Molecules | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 14 | Neurotransmitter | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Properties of Neurotransmitterand Types of Neurotransmitters | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 16 | Overview | Should study presentations and textbooks | Öğretim Yöntemleri: Tartışma |
| 17 | Term Exams | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 12 | 12 |
| Total Workload (Hour) | 104 | ||
| Total Workload / 25 (h) | 4,16 | ||
| ECTS | 4 ECTS | ||