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Information
| Code | EFR501 |
| Name | Basic Concepts of Pharmacokinetics and Pharmacodynamics |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Doç. Dr. HACER SİNEM BÜYÜKNACAR
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Explain the basic pharmacokinetic and pharmacodynamic concepts. Learns the definition of the drug, the stages it goes through in the body and lists the mechanisms of action of the drugs. Comprehends the basic principles of absorption, distribution and excretion of drugs, mechanisms of action of drugs, factors that change drug effects, and undesirable effects of drugs.
Course Content
Fundamental concepts of drugs, drug administration routes, passage of drugs through biological membranes, pharmacokinetic and pharmacodynamic events related to drugs, dose-concentration-effect relationships, factors that change the effect of drugs, drug interactions
Course Precondition
None
Resources
1-Kayaalp S. Oğuz Medical Pharmacology for Rational Treatment 1 and 2 vols. Pelikan Publications 2019. 2-Katzung Bertram G. Basic and Clinical Pharmacology McGraw-Hill Medical Books 2018. 3-Brunton Knollmann Dandan Laurence, Bjorn, Randa Hilal Goodman and Gilman's The Pharmacological Basis of Therapeutics-13 th Edition McGraw-Hill Medical Books 2018. 4- Ritter, Flower, Henderson, Rang James, Rod, Graeme, Humphrey Rang Dale's Pharmacology 8th Edition Churchill Livingstone,2016
Notes
lecture notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explain the basic concepts of pharmacology. |
| LO02 | Comprehends the basic features of drug action. |
| LO03 | List the branches of pharmacology. |
| LO04 | Explains classification of drugs, naming of drugs, equivalence concepts. |
| LO05 | Explains the passage and absorption of drugs through biological membranes and lists drug administration routes. |
| LO06 | Explain the distribution and biotransformation of drugs, comprehend the role of liver microsomal enzymes in drug metabolism. |
| LO07 | Explains the excretion and excretion routes of drugs. |
| LO08 | Explain the mechanisms of action of drugs. |
| LO09 | Explains pharmaceutical, pharmacodynamic and pharmacokinetic interactions. |
| LO10 | Explain the importance of the metabolism and effects of drugs according to genetic differences between individuals. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Explain the mechanisms of action of drugs, their pharmacokinetic and pharmacodynamic effects. | 5 |
| PLO02 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Acts in accordance with ethical and legal principles in the field of pharmacology. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Can project and conduct research in the field of pharmacology and analyze and interpret data. | |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | It plays an active role in rational drug use and provides counseling to the patient for the correct use of the drug. | 2 |
| PLO05 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Can convey the current developments or studies in the field of pharmacology verbally or in writing. | 2 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Follows scientific literature and current developments in the field of pharmacology. | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Establishes a relationship between the effects, mechanisms of action and drug interactions of drugs. | 5 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Explain the physiopathology of various diseases and evalue the drugs used in the treatment of these diseases. | 4 |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Knows and uses good laboratory practices. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Uses the theoretical and applied knowledge gained in the field of pharmacology. | |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have the ability to take part in in vitro/in vivo animal studies. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Explaining the importance of the course, its operation and evaluation method to the student. Introduction to pharmacology | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap |
| 2 | Passage of Drugs through Biological Membranes and Absorption | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Routes of Administration of Drugs | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Distribution of Drugs | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Biotransformation of Drugs | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Excretion and Elimination Kinetics of Drugs | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Dose Concentration Effect Relationship | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | General review | Ölçme Yöntemleri: Sözlü Sınav, Performans Değerlendirmesi, Ödev |
| 9 | Mechanism of Action of Drugs | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Receptor and Drug-Receptor Relationship | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Factors Changing the Effect of Drugs | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Interactions Between Drugs | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Toxic Effects of Drugs and Basic Concepts of Toxicology | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Pharmacogenetics | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Basic Principles in the Treatment of Acute Drug Intoxication | Reading the relevant part of the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Repetition of topics | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Repetition of topics | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 9 | 9 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 113 | ||
| Total Workload / 25 (h) | 4,52 | ||
| ECTS | 5 ECTS | ||