TÜRKÇE
ENGLISH
Information
| Code | VTS144 |
| Name | Methods of Discovery New Drugs |
| Term | 2024-2025 Academic Year |
| Semester | 2. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Label | FE Field Education Courses E Elective |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi ZEYNEP ÖZDEMİR KÜTAHYA |
| Course Instructor |
Dr. Öğr. Üyesi ZEYNEP ÖZDEMİR KÜTAHYA
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The aim of the course is to define new drug development and active drug substance synthesis strategies.
Course Content
The course includes topics on the correct synthesis of drugs from various raw materials, the synthesis of active pharmaceutical raw materials and the development of synthesis methods.
Course Precondition
None.
Resources
S. Oğuz Kayaalp. Principles of Clinical Pharmacology and Basic Regulations. Pelikan Yayıncılık Ltd. Şti., 2013, 5.Edition. ISBN: 978-605-5270-36-0
Notes
S. Oğuz Kayaalp. Principles of Clinical Pharmacology and Basic Regulations. Pelikan Yayıncılık Ltd. Şti., 2013, 5.Edition. ISBN: 978-605-5270-36-0
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Defines the original drug. |
| LO02 | Describes the equivalent (generic) drug. |
| LO03 | Summarizes drug/vaccine clinical development phases. |
| LO04 | Lists ways to find new drugs. |
| LO05 | Defines drug development based on combinatorial chemistry and high-throughput screening methods. |
| LO06 | Explains drug molecule design and virtual scanning with the help of computer. |
| LO07 | Refers to the contribution of advances in biotechnology, genomics and pharmacogenomics to drug development. |
| LO08 | Explains the importance of economic incentives and the expenditure/earnings profile in new drug development. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Distinguishes animal species and breeds based on their structural (morphological), functional (physiological, biochemical) and behavioral characteristics and whether they can be consumed for food purposes. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Explains the sources, physical and chemical properties and preparation of drugs. | |
| PLO03 | Bilgi - Kuramsal, Olgusal | Describes the effects and side effects of medications on patients | 3 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Explains the formation mechanisms of animal diseases and their pathological effects on the body. | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | It makes efficiency evaluations among animal breeds and, when necessary, carries out selection, hybridization and artificial insemination at a level that can carry out breeding work. | 4 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Disposes of dead animal material, tissue samples, medical and chemical waste appropriately in accordance with international, national laws and regulations. | |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | It determines the correct approach area for the patient by evaluating the examination, operation etc. practices in the clinic according to the topographic anatomy. | |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Uses biochemical parameters in diagnostic processes by evaluating the information obtained with cause-effect relationships. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Writes prescriptions in accordance with diagnosis and treatment protocols for diseases and poisoning in animals. | 2 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Implements necessary measures, including biosecurity, to control infectious diseases. | 5 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Performs necropsy to evaluate findings in dead animals, directs tissues to the necessary laboratory according to appropriate storage methods and prepares a report. | |
| PLO12 | Beceriler - Bilişsel, Uygulamalı | Monitors patients in the post-operative process according to the main treatment methods of surgical diseases in animal species. | |
| PLO13 | Beceriler - Bilişsel, Uygulamalı | Applies sedation, anesthesia and pain management methods safely according to animal species. | |
| PLO14 | Beceriler - Bilişsel, Uygulamalı | Correctly applies biosafety principles such as sterilization of clinical and laboratory equipment and clothing. | |
| PLO15 | Beceriler - Bilişsel, Uygulamalı | It regulates the care and feeding protocols according to animal species and supervises the consumption of animal foods produced for human consumption or foods containing animal products in their composition. | |
| PLO16 | Beceriler - Bilişsel, Uygulamalı | Evaluates laboratory results of animal diseases and applies correct diagnosis, prognosis and treatment methods based on the data obtained. | |
| PLO17 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | He/she is conscious of performing his/her profession by being aware of his/her powers and responsibilities. | |
| PLO18 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Examines scientific techniques and methods according to facts related to veterinary services and takes analysis or methodological responsibility for problems. | |
| PLO19 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It uses adequate technology in the hygienic production, manufacturing, processing, consumption and sales of food by conducting health control of animal food products produced for human consumption. | |
| PLO20 | Yetkinlikler - Öğrenme Yetkinliği | Lists the methods of producing and using scientific knowledge in his/her professional field. | |
| PLO21 | Yetkinlikler - Öğrenme Yetkinliği | Uses updated legislation regarding veterinary services when necessary. | |
| PLO22 | Yetkinlikler - Öğrenme Yetkinliği | Performs an examination appropriate to the case, applying the contribution of imaging methods to diagnosis and radiation safety in accordance with current regulations. | |
| PLO23 | Yetkinlikler - Öğrenme Yetkinliği | Keeps clinical and patient records using proper and scientific methods. | |
| PLO24 | Yetkinlikler - Öğrenme Yetkinliği | By observing the basic principles of medicine, it develops management methods and appropriate management plans for animal production enterprises. | |
| PLO25 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Implement social projects and plans with social awareness, based on professional skills and authority with a computer usage license, advanced computer software. | |
| PLO26 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Works in cooperation with other colleagues by following the world agenda within the framework of professional ethics and deontology rules. | |
| PLO27 | Yetkinlikler - Alana Özgü Yetkinlik | Produces solutions to field-specific problems in line with scientific data/evidence. | |
| PLO28 | Yetkinlikler - Alana Özgü Yetkinlik | He/she has the ethical values of the veterinary profession and defends these values. | |
| PLO29 | Yetkinlikler - Alana Özgü Yetkinlik | Takes appropriate precautions by clinically recognizing zoonosis and notifiable diseases. | |
| PLO30 | Yetkinlikler - Alana Özgü Yetkinlik | Determines the methods of diagnosis, prevention, treatment and operation of diseases in different animal species. | 3 |
| PLO31 | Yetkinlikler - Alana Özgü Yetkinlik | In emergency cases, intervenes in all animals and applies first aid methods. | |
| PLO32 | Yetkinlikler - Alana Özgü Yetkinlik | Makes judgments on animal husbandry principles and breeding by assessing the physical condition, welfare and rearing conditions of domestic animals, communicating appropriately with animal owners and colleagues. | |
| PLO33 | Yetkinlikler - Alana Özgü Yetkinlik | Independently interprets articles and presentations published in other scientific fields related to Veterinary Medicine to maintain professional development and skills. | |
| PLO34 | Yetkinlikler - Alana Özgü Yetkinlik | When necessary, euthanizes animals using appropriate methods and respecting the feelings of animal owners. | |
| PLO35 | Yetkinlikler - Alana Özgü Yetkinlik | By mastering the concepts of occupational safety in terms of the workplace and the personnel working with it, they have the competence to apply and defend it. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Original drug, equivalent drug definition | Lecture notes, books | Öğretim Yöntemleri: Anlatım |
| 2 | Drug/vaccine clinical development phases | Lecture notes, current news, books | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Finding medicine using folk remedies and natural resources | Lecture notes, visual source | Öğretim Yöntemleri: Anlatım, Tartışma |
| 4 | Drug development by modifying or imitating drugs of natural origin | Lecture notes, books | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Finding new target molecules with functional importance in the body and designing chemical substances that activate or inhibit them | Lecture notes, books, current articles | Öğretim Yöntemleri: Anlatım, Tartışma |
| 6 | Drug development by mimicking endogenous active substances such as neuromediators, hormones, autocoids and cytokines | Lecture notes, books | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Finding a drug by imitating another company's drug | Lecture notes | Öğretim Yöntemleri: Anlatım |
| 8 | Mid-Term Exam | Question preparation | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Developing new drugs by examining the side effects of existing drugs | Lecture notes, books, current articles | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Finding a drug by a relatively random approach or by chance | Lecture notes, books | Öğretim Yöntemleri: Anlatım |
| 11 | Drug development based on combinatorial chemistry and high-throughput screening methods | Lecture notes, books, current articles | Öğretim Yöntemleri: Anlatım, Tartışma |
| 12 | Computer-assisted drug molecule design and virtual scanning | Lecture notes, current articles | Öğretim Yöntemleri: Anlatım |
| 13 | The impact of biotechnology on drug development and production | Lecture notes, current news | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Contribution of developments in genomics and pharmacogenomics to drug development | Lecture notes, current news, books | Öğretim Yöntemleri: Anlatım, Tartışma |
| 15 | Importance of economic incentives and expenditure/earnings profile in new drug development | Lecture notes, books | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Question preparation | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Question preparation | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 2 | 2 |
| Final Exam | 1 | 4 | 4 |
| Total Workload (Hour) | 90 | ||
| Total Workload / 25 (h) | 3,60 | ||
| ECTS | 4 ECTS | ||