BİO523 Developmental Biology and Genetics

4 ECTS - 2-0 Duration (T+A)- . Semester- 2 National Credit

Information

Code BİO523
Name Developmental Biology and Genetics
Term 2024-2025 Academic Year
Semester . Semester
Duration (T+A) 2-0 (T-A) (17 Week)
ECTS 4 ECTS
National Credit 2 National Credit
Teaching Language Türkçe
Level Yüksek Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Prof. Dr. DAVUT ALPTEKİN


Course Goal / Objective

Development of embryo, first differentiation in development, stem cells, genes that add to development, programmed cell death (apoptosis) is to have information about.

Course Content

General information about developmental biology and genetics. Formation of zygote, beginning of division, beginning of differentiation, morphogenesis, growth and organism formation. Stem Cells (Totipotent stem cells, Pluripotent stem cells, Multipotent stem cells). Embryonic development and factors affecting cell differentiation. The effect of nucleus. Cytoplasm content and effect of segmentation. Cell-cell effect (Hormones and Environmental Factors). Genome equivalence. Cloning. Genes that are effective in development. Double on-off systems. Maternal-acting genes in embryo formation. Zygotic genes in embryo formation. Drosophyla also segmentation model. The genes involved in this model are; Gap genes. Drosophyla also segmentation model. The genes involved in this model are; Double rule genes, Segment polarity genes. An overview of the development of Caenorhabditis elegans. Programmed cell death.

Course Precondition

None

Resources

Developmental Biologyİ. SCOTT.GILBERT, Çeviri Editörleri: Prof.Dr. Melike ERKAN, Prof.Dr. Tülay İREZ. Nobel TIP Kitabevi, 2013

Notes

Lecturer Lecture Notes and Slides


Course Learning Outcomes

Order Course Learning Outcomes
LO01 To have general information about Developmental Biology and Genetics.
LO02 Learn about the formation of the zygote, the beginning of the division, the beginning of differentiation, morphogenesis, growth and formation of organisms.
LO03 Learns the basic information about Stem Cells (Totipotent stem cells, Pluripotent stem cells, Multipotent stem cells).
LO04 Learns the factors affecting embryonic development and cell differentiation.
LO05 Learns the effect of nucleus, cytoplasm content and segmentation on development.
LO06 Have knowledge about cell-cell effect (Hormones and Environmental Factors).
LO07 Learns what genome equivalence is.
LO08 Learns genes that are effective in cloning and development (HOX genes).
LO09 Have knowledge about double on-off system genes.
LO10 Learns the effect of maternal effective genes in embryo formation.
LO11 Learn the effect of zygotic genes in embryo formation.
LO12 Segmentation model in Drosophyla. To have knowledge about gap genes in this model.
LO13 Segmentation model in Drosophyla. Have knowledge about double rule genes and segment polarity genes in this model.
LO14 Have information about the development of Caenorhabditis elegans from animal models in development.
LO15 Learns programmed cell death (Apoptosis).


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal To comprehend the structure and functions of cells and organelles which constitute the basic structure of life 1
PLO02 Bilgi - Kuramsal, Olgusal To recognize the functions of tissue and organ systems 2
PLO03 Bilgi - Kuramsal, Olgusal To examine the structure of genetic material 1
PLO04 Bilgi - Kuramsal, Olgusal To recognize genetic diseases and genes that cause these diseases 1
PLO05 Bilgi - Kuramsal, Olgusal To learn the structure of genes 1
PLO06 Bilgi - Kuramsal, Olgusal To define chromosome and gene mutations
PLO07 Bilgi - Kuramsal, Olgusal To classify heredity forms (autosomal dominant, autosomal recessive, gender-dependent dominant and recessive inheritance models)
PLO08 Bilgi - Kuramsal, Olgusal To use molecular and cytogenetic analysis 1
PLO09 Bilgi - Kuramsal, Olgusal To be able to explain the numerical and structural anomalies of autosomal and sex chromosomes
PLO10 Bilgi - Kuramsal, Olgusal To make DNA isolation from all kinds of tissues
PLO11 Bilgi - Kuramsal, Olgusal To prepare PCR
PLO12 Bilgi - Kuramsal, Olgusal To make and interpret agarose and polyacrylamide gel electrophoresis
PLO13 Bilgi - Kuramsal, Olgusal To measure the obtained DNA on the spectrophotometer
PLO14 Bilgi - Kuramsal, Olgusal To apply and interpret QF-PCR technique
PLO15 Bilgi - Kuramsal, Olgusal To make cell culture from blood, amnion, chorionic villus biopsy specimens and to obtain chromosome preparation
PLO16 Bilgi - Kuramsal, Olgusal To perform karyotype analysis of chromosome preparations and to recognize and interpret all human chromosomes
PLO17 Beceriler - Bilişsel, Uygulamalı To interpret a scientific article and to learn how to write a paper 4


Week Plan

Week Topic Preparation Methods
1 General information about Developmental Biology and Genetics. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
2 Formation of zygote, beginning of division, beginning of differentiation, morphogenesis, growth and organism formation. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
3 Stem Cells (Totipotent stem cells, Pluripotent stem cells, Multipotent stem cells) Preparation of presentation. Öğretim Yöntemleri:
Anlatım
4 Embryonic development and factors affecting cell differentiation. The effect of nucleus. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
5 Cytoplasm content and effect of segmentation. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
6 Cell-cell effect (Hormones and Environmental Factors). Preparation of presentation. Öğretim Yöntemleri:
Anlatım
7 Genome equivalence. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
8 Mid-Term Exam Exam question preparation Ölçme Yöntemleri:
Yazılı Sınav
9 The Cloning. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
10 Genes that are effective in development. Double on-off systems. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
11 Maternal-acting genes in embryo formation. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
12 Zygotic genes in embryo formation. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
13 Segmentation model in Drosophyla. The genes involved in this model are; Gap genes (Gap genes). Preparation of presentation. Öğretim Yöntemleri:
Anlatım
14 Segmentation model in Drosophyla. The genes involved in this model are; Double rule genes, Segment polarity genes. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
15 Overview of the development of Caenorhabditis elegans. Programmed cell death. Preparation of presentation. Öğretim Yöntemleri:
Anlatım
16 Term Exams Exam question preparation Ölçme Yöntemleri:
Yazılı Sınav
17 Term Exams Exam question preparation Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 2 28
Out of Class Study (Preliminary Work, Practice) 14 2 28
Assesment Related Works
Homeworks, Projects, Others 4 10 40
Mid-term Exams (Written, Oral, etc.) 1 1 1
Final Exam 1 2 2
Total Workload (Hour) 99
Total Workload / 25 (h) 3,96
ECTS 4 ECTS

Update Time: 26.09.2024 11:56