TÜRKÇE
ENGLISH
Information
| Code | MİK614 |
| Name | Antifungal Drugs and Susceptibility Testing |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET MACİT İLKİT |
Course Goal / Objective
To learn the general properties, classifications, action and resistance mechanisms of antifungal agents in diseases caused by fungi and the methods used in antifungal susceptibility testing.
Course Content
In vitro testing of the efficacy of two or more antifungals with the aim of determining in vitro, - To monitor the development of resistance within a susceptible population, - The efficacy of a newly discovered experimental drug determination of
Course Precondition
Have general information about fungi and know basic antifungal drugs
Resources
1- EUCAST Clinical and/or epidemiologically important resistance mechanisms and resistance detection guide 2. CLSI antibiotic susceptibility tests and breakpoint standards
Notes
www.nfid.org, www.cdc.gov.fungal
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Know the principles of antimicrobial activity tests. |
| LO02 | learns the antifungal agents and their mechanisms of action that are on the agenda today. |
| LO03 | Knows the mechanisms of resistance to antifungal agents. |
| LO04 | How antifungal susceptibility tests are performed |
| LO05 | Know the principles of antimicrobial testing. |
| LO06 | Knows the general properties of antifungal agents in diseases caused by fungi. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Having acquired technical skills through laboratory studies, being able to access information, conduct research, plan experiments, solve problems, interpret experimental results, make presentations, develop strategies on microbiology-related issues | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Having received a quality microbiology education at a standard accepted in international platforms, having broadened scientific horizons and being preferred in many sectors related to microbiology, being competent in microbiology | 3 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Isolates infectious agents | 2 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Performs the steps of identifying infectious agents | 1 |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Knowing and applying laboratory methods used in general bacteriology, virology, parasitology, mycology and immunology at theoretical and practical levels | 3 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Being aware of ethical values and problems in the field of microbiology | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Ability to make critical evaluations on published research in the field of microbiology | |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Gaining the competence to present a research conducted in the field of microbiology in written, oral and visual form and prepare it for publication | 3 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Having acquired research and career ethics | 2 |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Having deepened knowledge on specific subjects studied (thesis study) | 4 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Antifungal agents, antimicrobial chemotherapeutic definitions | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | 1950s to present: changing antifungal drug spectrum (Yeast-Mold) | Course resources and book | Öğretim Yöntemleri: Anlatım, Tartışma |
| 3 | Classification of antifungal agents according to their mechanism of action (cell wall) | Course resources and book | Öğretim Yöntemleri: Anlatım, Tartışma |
| 4 | Classification of antifungal agents according to their mechanism of action(cytoplasmic membrane) | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Classification of antifungal agents according to their mechanism of action(protein synthesis) | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Classification of antifungal agents according to their mechanism of action(nücleic acid) | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Classification of antifungal agents according to their mechanism of action(antimetabolit) | Course resources and book | Öğretim Yöntemleri: Anlatım, Tartışma |
| 8 | Exam | Course resources and book | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Problems brought about by antifungal resistance | Course resources and book | Öğretim Yöntemleri: Anlatım, Tartışma |
| 10 | Primary and secondary resistance in fungi | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Antifungal susceptibility tests, dilution and diffusion tests | Course resources and book | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 12 | Detection of resistance in vitro:Antifungal susceptibility tests -I | Course resources and book | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 13 | Detection of resistance in vitro:Antifungal susceptibility tests-II | Course resources and book | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 14 | Host resistance in antifungal | Course resources and book | Öğretim Yöntemleri: Anlatım, Tartışma |
| 15 | Resistance according to species:Literature study | Course resources and book | Öğretim Yöntemleri: Anlatım, Deney / Laboratuvar |
| 16 | Exam | Course resources and book | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Exam | Course resources and book | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 7 | 7 |
| Final Exam | 1 | 18 | 18 |
| Total Workload (Hour) | 109 | ||
| Total Workload / 25 (h) | 4,36 | ||
| ECTS | 4 ECTS | ||