TÜRKÇE
ENGLISH
Information
| Code | FAR645 |
| Name | Membrane transporters and drug responses |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET ATA SEÇİLMİŞ |
Course Goal / Objective
To educate students who are knowledgeable about the relationship between membrane transporters and pharmacological responses and/or adverse effects given to drugs, their structure and functions, the interaction of drugs with membranes, and the effective mechanisms during the passage of drugs into the cell.
Course Content
Cell membrane and its functions, Transport mechanisms, Transport proteins, Transport kinetics, Membrane transporters and adverse drug responses, Functional importance of membrane transporters in therapeutic drug response, relationship between membrane transporters and adverse drug responses. Membrane transport kinetics and mechanism, active and active transporters, Transporter superfamilies in the human genome
Course Precondition
None
Resources
1. Basic and Clinical Pharmacology (Katzung), 2. The Pharmacologıcal Basıs of Therapeutıcs (Goodman and Gilman), 3. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp
Notes
Internet and library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Know the functional role of membrane transporters in therapeutic drug responses. |
| LO02 | Know the functional role of membrane transporters in adverse drug responses. |
| LO03 | Know the basic mechanisms of membrane transport. |
| LO04 | Know the kinetics of transport across the membrane. |
| LO05 | Know the carrier superfamilies in the human genome |
| LO06 | Know the hepatic and renal transporters involved in pharmacokinetics. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Discusses the mechanisms of action, side effects, and toxic effects of drugs. | 2 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Explains drug effects, drug interactions and effects on organ systems with a systematic approach | 3 |
| PLO03 | Yetkinlikler - Alana Özgü Yetkinlik | Plans, implements and finalizes a scientific project | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Recognize the research areas and research techniques of pharmacology | 1 |
| PLO05 | Yetkinlikler - Alana Özgü Yetkinlik | Comparatively examines and compiles scientific articles in the field of pharmacology. | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Prepares the experimental setup for an in vitro or in vivo pharmacological study and solves problems. | |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | He/she transforms the data obtained from the research project into a scientific research article. | 1 |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Evaluates drug use and its effects in society due to his/her knowledge about drugs. | 2 |
| PLO09 | Bilgi - Kuramsal, Olgusal | Explain clinical phase studies in drug development. | 1 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Evaluates and interprets study data statistically. | 1 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | contributes to public health with its awareness of rational drug use. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Membrane transporters in therapeutic drug response | Pharmacology Textbooks | Öğretim Yöntemleri: Soru-Cevap, Anlatım |
| 2 | Membrane transporters and adverse drug responses | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Basic mechanisms of membrane transport | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Kinetics of transport across the membrane | Pharmacology Textbooks | Öğretim Yöntemleri: Soru-Cevap, Anlatım |
| 5 | Vectorial transport.. | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Carrier structure and mechanism | Pharmacology Textbooks | Öğretim Yöntemleri: Soru-Cevap, Anlatım |
| 7 | Carrier superfamilies in the human genome | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Pharmacology Textbooks | Ölçme Yöntemleri: Ödev |
| 9 | Tissue distribution of drug-associated ABC transporters | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Genetic variation in membrane transporters. Its significance in clinical drug response. | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Transporters involved in pharmacokinetics | Pharmacology Textbooks | Öğretim Yöntemleri: Soru-Cevap, Anlatım |
| 12 | Hepatic transporters | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Renal transporters | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Transporters and pharmacodynamics. drug action in the brain | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Blood-brain barrier and Blood-cerebrospinal fluid barrier | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exams | Pharmacology Textbooks | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Pharmacology Textbooks | Ölçme Yöntemleri: Sözlü Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 114 | ||
| Total Workload / 25 (h) | 4,56 | ||
| ECTS | 5 ECTS | ||