TÜRKÇE
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Information
| Code | FAR631 |
| Name | Otacoids |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. NURAN ÖĞÜLENER |
| Course Instructor |
Prof. Dr. NURAN ÖĞÜLENER
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
It is aimed to explain the classifications, effects, receptors mediating their effects, mechanisms of action, their roles in physiological and physiopathological events, indications, contraindications and side effects of autacoids and their antagonists.
Course Content
Classification of autocoids, physiological effects, receptors, mechanisms of action, roles in the pathophysiology of diseases, pharmacological effects of autoacoids and their antagonists, mechanisms of action, indications, side effects, contraindications for use
Course Precondition
None
Resources
1-Katzung and Trevor’s Pharmacology 2-Goodman &Gilman's The Pharmacological Basis of Therapeutics 3-Integrated Pharmacology
Notes
Internet and library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Define and classify autocoids. |
| LO02 | They classify histamine receptors, explain their localization and mediated processes. |
| LO03 | Defines histamine preparations and their clinical use. |
| LO04 | Explain the pharmacological effects, indications, side effects and contraindications of H1 receptor blockers. |
| LO05 | Explain the pharmacological effects, indications, side effects and contraindications of H2 receptor blockers. |
| LO06 | Explain the physiological and pharmacological effects of serotonin and the physiopathological events in which it plays a role. |
| LO07 | Explain the indications, side effects and contraindications of serotonin and its antagonists. |
| LO08 | Lists the pharmacological effects, indications, side effects and contraindications of angiotensin synthesis inhibitors and receptor blockers. |
| LO09 | Explain the endothelin, endothelin receptors, the importance of endothelins in physiological and pathological events and the roles of endothelins in the treatment approach. |
| LO10 | Lists nitric oxide synthesis, physiological and physiological effects, mechanisms of action, contribution to physiopathological events and its role in treatment approach. |
| LO11 | Explain the synthesis of hydrogen sulfide, its physiological and pharmacological effects, its mechanisms of action, its contribution to physiopathological events and its role in the treatment approach. |
| LO12 | Explain the indications, side effects and contraindication of drugs that block eicosanoid synthesis and receptors. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Discusses the mechanisms of action, side effects, and toxic effects of drugs. | 3 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Explains drug effects, drug interactions and effects on organ systems with a systematic approach | 4 |
| PLO03 | Yetkinlikler - Alana Özgü Yetkinlik | Plans, implements and finalizes a scientific project | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Recognize the research areas and research techniques of pharmacology | |
| PLO05 | Yetkinlikler - Alana Özgü Yetkinlik | Comparatively examines and compiles scientific articles in the field of pharmacology. | 2 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Prepares the experimental setup for an in vitro or in vivo pharmacological study and solves problems. | |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | He/she transforms the data obtained from the research project into a scientific research article. | |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Evaluates drug use and its effects in society due to his/her knowledge about drugs. | 2 |
| PLO09 | Bilgi - Kuramsal, Olgusal | Explain clinical phase studies in drug development. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Evaluates and interprets study data statistically. | |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | contributes to public health with its awareness of rational drug use. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Autoacoid, Classification of Autoacoids According to Their Structures | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 3 | What is Histamine? What is the Structure, Source, Synthesis and Metabolism of Histamine? What are the Pharmacological Effects, Physiological and Pathological Roles, Receptors and Preparations of Endogenous Histamine? Classification of Antihistamines, Effects, Indications for Use, Side Effects, Contraindicated Conditions. | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | What is Serotonin? How Does Serotonin Synthesis, Storage and Metabolism Happen? Tissues Where Serotonin is Synthesized, Serotonin Receptors, Pharmacological Effects of Serotonin, Its Importance in Physiological and Pathological Events, Indications of Antagonists, Side Effects, Contraindications. | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | What Are Peptide Autoacoids? What is Angiotensin? Synthesis, Receptors, Pharmacological Effects of Angiotensin, Its Importance in Physiological and Pathological Events and Indications, Side Effects, Contraindications and Interactions of Angiotensin Antagonists. | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | What Is Quinines And The Kalikrein-Kinin System? Kinin's Receptors, Effects of Kinins, Their Roles in Physiological and Pathological Events, Their Roles in Treatment Approaches | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 7 | What Are Natriuretic Peptides? What are the receptors of natriuretyl peptides, their effects, their importance in physiological and pathological events, and their role in treatment approaches? | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 8 | Mid-Term Exam | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | What are Urotensin II, Its Receptors, Effects, Importance in Pathological Events and Roles in Treatment Approaches. | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | What is Nitric Oxide? Nitric Oxide Synthesis, Metabolism, Effects, Effect Mechanisms and Role in Treatment Approaches. | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Tartışma |
| 11 | What is Hydrogen Sulfide? Synthesis, Metabolism, Effects, Effect Mechanisms and Role of Hydrogen Sulfide in Treatment Approaches. | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 12 | What is Carbon Monoxide? Synthesis, Metabolism, Effects, Effect Mechanisms and Role of Carbon Monoxide in Treatment Approaches? What is Endothelium-Derived Hyperpolarizing Factor and Epithelial-Derived Relaxing Factor? | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 13 | Synthesis, Release, Metabolism, Pharmacological and Physiological Effects of Cyclooxygenase Products, What are Protaglandins Used as Medicines? Leukotrienes and Other Lipoxygenase Products. | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 14 | Eicosanoid Synthesis Inhibitors and Receptor Blocking Drugs. Other Autocoids | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 15 | Overview | should study to presentations | Öğretim Yöntemleri: Tartışma, Beyin Fırtınası |
| 16 | Term Exams | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 24 | 24 |
| Total Workload (Hour) | 88 | ||
| Total Workload / 25 (h) | 3,52 | ||
| ECTS | 4 ECTS | ||