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Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| HEALTH PHYSICS (MASTER) (WITH THESIS) | |
| Code | MEDF508 |
| Name | Radiobiology |
| Term | 2025-2026 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof.Dr. İSMAİL GÜNAY |
| Course Instructor |
Prof. Dr. IŞIL ÖCAL
(Bahar)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The aim of this course is to teach and apply the effects of radiation on molecules and cells, cell survival curves, and the effects of divided dose-rate radiation.
Course Content
The physics and chemistry of radiation absorption, molecular mechanisms of DNA and chromosome damage and repair, cell survival curves, radiation sensitivity and cellular senescence in the mitotic cycle, split radiation and dose-rate effect, oxygen effect and oxygenation, radiation and cancer formation, hereditary effects of radiation, effects of radiation on embryos and fetuses, midterm exam, final exam, assignments.
Course Precondition
There are no prerequisites.
Resources
Radiation Science for Technologists, Bushong S, 2013 Radiology for Radiobiologists, Eric J Hall, mato J. Giaccia, Wolters Kluwer, Philadelphia, 2012 Radyasyon biyoloji ve korunmanın esasları, Steve Forshier, Delmar GEGAGR Lerning, 2002 Radiation biology and the fundamentals of protection, Steve Forshier, Delmar Gegagr Lenning, 2002
Notes
Internet research
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows the physics and chemistry of radiation absorption. |
| LO02 | They learn the molecular mechanisms of DNA and chromosome damage and repair. |
| LO03 | Knows cell survival curves. |
| LO04 | Learns about the effect of split radiation and dose-rate. |
| LO05 | Understands the effect of split radiation and dose-rate in clinical practice. |
| LO06 | Learns about the effect of oxygen and oxygenation. |
| LO07 | Learn about the hereditary effects of radiation. |
| LO08 | Learn about the effects of radiation on the embryo and fetus. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Learn the basics of the field | |
| PLO02 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | To be able to set up an experimental setup and work in the laboratory. | 2 |
| PLO03 | Yetkinlikler - Öğrenme Yetkinliği | Being able to prepare a project proposal on your own | |
| PLO04 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | be able to plan an experimental research | 2 |
| PLO05 | Yetkinlikler - Alana Özgü Yetkinlik | To report the results of the research | 1 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To be able to interpret research findings | |
| PLO07 | Bilgi - Kuramsal, Olgusal | To have an analytical thinking mechanism related to the field, To reach reliable information, To be able to create and write a research project, To be able to work and research in accordance with ethical values. | 1 |
| PLO08 | Bilgi - Kuramsal, Olgusal | To be able to systematically transfer the theoretical knowledge he has researched to the audience. To transfer the acquired knowledge to the public effectively | |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have a scientific thinking systematic in relation to their profession | |
| PLO10 | Yetkinlikler - Öğrenme Yetkinliği | To learn how to plan research | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | The physics and chemistry of radiation absorption. | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Molecular mechanism of DNA and chromosome damage and repair-1 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Molecular mechanism of DNA and chromosome damage and repair-2 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Cell survival curves-1 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Cell survival curves-2 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Radiation sensitivity and cellular senescence in the mitotic cycle. | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma |
| 7 | Split radiation and dose-rate effect-1 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | The student reads the relevant section before the lesson. | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev |
| 9 | Split radiation and dose-rate effect-2 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Oxygen effect and oxygenation-1 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Oxygen effect and oxygenation-2 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Radiation and Cancer Formation - Part 1 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Radiation and Cancer Formation - Part 2 | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Hereditary effects of radiation | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | The effects of radiation on the embryo and fetus. | The student reads the relevant section before the lesson. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | The student reads the relevant section before the lesson. | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev |
| 17 | Term Exams | The student reads the relevant section before the lesson. | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 18 | 18 |
| Total Workload (Hour) | 86 | ||
| Total Workload / 25 (h) | 3,44 | ||
| ECTS | 3 ECTS | ||