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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOLOGY (MASTER) (WITH THESIS) | |
| Code | BY778 |
| Name | Circadian rhythms in health and disease |
| Term | 2026-2027 Academic Year |
| Term | Fall |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Belirsiz |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi ÖZGECAN KAYALAR |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
Understanding cellular activities and the mechanisms that regulate these activities has an important place for innovative drug development studies. Within the scope of the course, the biological clock and its types; the control mechanisms of the biological clock at the cellular and organismal level, its relationship with our health; drug research on the biological clock and the importance of chronotherapy will be examined, so the course will be a guide for the development of innovative biotechnological drugs.
Course Content
Introduction to circadian rhythm and biological clock concepts, history and basic terms; evolution of circadian rhythms across species and conserved mechanisms; an overview of biological timing mechanisms from single cells to humans; fundamentals of circadian rhythm; circadian rhythm and photoperiodism; circadian pacemaker systems and analysis methods; genes responsible for circadian rhythm and their expression control mechanisms, the relationship between circadian rhythm and inflammation; circadian rhythm and metabolism; the relationship between circadian rhythm and chronic diseases; the relationship between circadian rhythm and cancer; the relationship between circadian rhythm and sleep disorders and diseases; chronotherapy; student presentations.
Course Precondition
None
Resources
1. Chronobiology : biological timekeeping. Ed: Jay C.Dunlop, Jennifer J. Loros, Patricia J. DeCoursey, Sinauer Associates , Inc.Publishers, 2004. 2. Gunter Klein. Farewell to the Internal Clock: a contribution in the field of chronobiology. Springer, 2007. 3. Sleep and Chronobiology in Plasticity and Memory. Ed: Jarry R.Gerstner, H. Craig Heller, Sara J Aton. Frontiers in Systems Neuroscience, 2016.
Notes
Current publications, websites, current books, current literature on the subject
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Defines the concepts of biological clock and circadian rhythm; explains evolutionary differences and similarities in biological timing mechanisms from single-celled organisms to humans |
| LO02 | It analyzes the key clock genes involved in the formation of the circadian rhythm, the expression control mechanisms of these genes, and the molecular feedback loops. |
| LO03 | Understands the working principles of circadian timer systems and interprets the current methods used in the analysis of these systems. |
| LO04 | Correlate the physiological and pathological effects of the circadian rhythm on inflammation, metabolic processes, chronic diseases, cancer development, and sleep disorders. |
| LO05 | Explains the concept of "Chronotherapy", which is the reflection of biological clock and circadian rhythm knowledge in medicine; evaluates the clinical importance of timing (dosage and drug interaction) in treatment processes. |
| LO06 | Reads and analyzes current scientific articles in the field of biological clocks; effectively conveys and discusses an academic topic using oral presentation techniques. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Identifies the interdisciplinary interaction that the field is related to. | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Interprets the knowledge gained in the field by integrating the information from different disciplines and creates new information. | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Carries out a study that requires expertise related to the field independently. | 2 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Evaluates the knowledge and skills acquired at the level of expertise in the field with a critical approach and directs its learning. | 1 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Supports the current developments in the field and their studies with quantitative and qualitative data and transmits them both in the field and outside the field systematically in written, oral and visual form. | 2 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | It supervises the social, scientific, cultural and ethical values in the collection, interpretation, application and announcement stages of the data related to the field and teaches these values. | |
| PLO08 | Bilgi - Kuramsal, Olgusal | The information they absorbed in the field; use problem solving and / or practical skills in interdisciplinary studies. | 3 |
| PLO09 | Bilgi - Kuramsal, Olgusal | It contributes to the solution of social, scientific, cultural and ethical problems encountered in the field and supports the development of these values. | |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Biyolojik Saate giriş Introduction to the Biological Clock | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Biological clock mechanism in microorganisms | Reading current lecture notes and related articles, internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | A look at biological timing mechanisms from single-celled to human | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | The Basics of Circadian Rhythm | Reading current lecture notes and related articles, internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Circadian Rhythm and Photoperiodism | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Circadian Pacemaker Systems and Analysis Methods | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama, Proje Temelli Öğrenme |
| 7 | Genes responsible for the Circadian Rhythm and the control mechanisms of their expression | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Beyin Fırtınası |
| 8 | Mid-Term Exam | General review | Ölçme Yöntemleri: Ödev, Sözlü Sınav, Yazılı Sınav, Performans Değerlendirmesi |
| 9 | The Relationship Between Circadian Rhythm and Inflammation | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Beyin Fırtınası, Alıştırma ve Uygulama |
| 10 | Circadian Rhythm and Metabolism | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama, Beyin Fırtınası |
| 11 | The Relationship of Circadian Rhythm with Chronic Diseases | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Alıştırma ve Uygulama, Beyin Fırtınası |
| 12 | The Relationship of Circadian Rhythm with Cancer | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama, Beyin Fırtınası |
| 13 | The Relationship of Circadian Rhythm with Sleep Disorders and Diseases | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama |
| 14 | Chronotherapy | Güncel ders notları ve ilgili makalelerin okunması, internet araştırması | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama, Beyin Fırtınası, Grup Çalışması |
| 15 | Student presentations | Reading current lecture notes and related articles, internet research | Öğretim Yöntemleri: Grup Çalışması, Beyin Fırtınası, Bireysel Çalışma |
| 16 | Term Exams | General review | Ölçme Yöntemleri: Ödev, Sözlü Sınav, Yazılı Sınav, Performans Değerlendirmesi |
| 17 | Term Exams | Written exam/Homework/Performance Evaluation | Ölçme Yöntemleri: Performans Değerlendirmesi, Ödev, Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||