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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOLOGY (MASTER) (WITH THESIS) | |
| Code | BY780 |
| Name | Molecular Biology of Cellular Signaling Mechanisms |
| Term | 2026-2027 Academic Year |
| Term | Fall |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Belirsiz |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi ÖZGECAN KAYALAR |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
To teach signal transfer from outside the cell to the cell and the functioning and control of intracellular signaling pathways with sample signaling pathways.
Course Content
Principles of cell signaling, basic signaling pathways, receptor types in the recognition of extracellular signals, signal coordination, protein phosphorylation, enzyme classes active in cell signaling, G proteins, inositol phosphates, intracellular calcium, redox signaling, mTOR, integrin and cadherin-mediated signaling, TGF-beta signaling, Wnt signaling, Notch receptor signaling, Hedgehog signaling, Toll-like receptor and NF-κB signaling, and molecular mechanisms of selected signaling pathways
Course Precondition
None
Resources
1. Cell Signaling 1st Edition by Wendell Lim (Author), Bruce Mayer (Author), Tony Pawson (Author), 2014. 2. Cell Signalling second edition, by John Hancock, 2010.
Notes
Current literature
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | It classifies the components that make up intracellular signaling systems (ligands, receptors, second messengers, effector proteins) according to their structural and functional properties. |
| LO02 | Explain the different types of intracellular communication, such as endocrine, paracrine, autocrine, and juxacrine, and the physiological contexts of these types. |
| LO03 | Compares the ligand-binding mechanisms of membrane receptors (GPCR, RTK, etc.) and nuclear/cytosolic receptors and the cellular response differences they trigger, comprehends, analyzes, and discusses their positions in the pathological mechanisms in which they play a role. |
| LO04 | Interprets the regulatory roles of G-protein-coupled receptors and protein kinases in signal transduction at the molecular level, comprehends, analyzes, and discusses their positions in the pathological mechanisms in which they play a role. |
| LO05 | Evaluates the central role of the mTOR signaling pathway on cell growth, proliferation, and metabolism and its interaction with other pathways, comprehends, analyzes, and discusses their position in the pathological mechanisms in which they are involved. |
| LO06 | Explains how mechanical stimuli are converted into biochemical signals (mechanotransduction) through integrins and cadherins, comprehends, analyzes and discusses their position in the pathological mechanisms in which they play a role. |
| LO07 | Explains the functioning of canonical and non-canonical signaling pathways, which have developmental and homeostatic importance, by defining the critical nodes in signal transduction, comprehends, analyzes and discusses their positions in the pathological mechanisms in which they play a role. |
| LO08 | Relates and discusses the role of disruptions in signal transduction mechanisms (mutations, overactivation or inhibition) in cancer and other chronic diseases with literature data. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Identifies the interdisciplinary interaction that the field is related to. | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Interprets the knowledge gained in the field by integrating the information from different disciplines and creates new information. | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Carries out a study that requires expertise related to the field independently. | 2 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Evaluates the knowledge and skills acquired at the level of expertise in the field with a critical approach and directs its learning. | 1 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Supports the current developments in the field and their studies with quantitative and qualitative data and transmits them both in the field and outside the field systematically in written, oral and visual form. | 2 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | It supervises the social, scientific, cultural and ethical values in the collection, interpretation, application and announcement stages of the data related to the field and teaches these values. | |
| PLO08 | Bilgi - Kuramsal, Olgusal | The information they absorbed in the field; use problem solving and / or practical skills in interdisciplinary studies. | 3 |
| PLO09 | Bilgi - Kuramsal, Olgusal | It contributes to the solution of social, scientific, cultural and ethical problems encountered in the field and supports the development of these values. | |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Components of Intracellular Signaling Systems and Their Functions | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Fundamental Mechanisms of Signal Transduction | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Molecules Involved in Signal Transduction | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Types of Intracellular Communication | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Receptor and Ligand Structures and Functions | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Receptors localised in the membrane, nuclear and cytosolic receptors | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Receptor-Binding Hormones and Their Functions | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | General review | Ölçme Yöntemleri: Ödev, Sözlü Sınav, Yazılı Sınav, Performans Değerlendirmesi |
| 9 | G Protein-Coupled Receptors and Mechanisms Governed by Protein Kinases | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası |
| 10 | mTOR Signalling Pathway | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası |
| 11 | Integrin- and Cadherin-mediated signal transduction | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası |
| 12 | Canonical and non-canonical TGF-Beta pathway | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası |
| 13 | Canonical and non-canonical Wnt signalling pathway | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası |
| 14 | Notch signalling pathway | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası |
| 15 | Sonic Hedgehog Signalling Pathway | Reading current lecture notes and related articles, and internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası |
| 16 | Term Exams | General review | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev, Performans Değerlendirmesi |
| 17 | Term Exams | Written exam, Homework, Performance Evaluation | Ölçme Yöntemleri: Yazılı Sınav, Ödev, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||