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Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| BIOSTATISTICS (MEDICINE) (MASTER) (WITH THESIS) | |
| Code | BİS508 |
| Name | Systematic Review and Meta Analysis |
| Term | 2026-2027 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 1-3 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2.5 National Credit |
| Teaching Language | Türkçe |
| Level | Belirsiz |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi Sevinç Püren YÜCEL KARAKAYA |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
The objective of this course is to teach the basic principles of systematic review and meta-analysis methods and to enable students to gain the skills to evaluate scientific evidence, systematically review the literature, synthesize data, and interpret results.
Course Content
This course covers introduction to systematic reviews, formulation of research questions, literature search methods, study selection, data extraction, risk of bias assessment, basic concepts of meta-analysis, effect size measures, heterogeneity, publication bias, interpretation of results, and reporting.
Course Precondition
No
Resources
Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2021). Introduction to meta-analysis. John wiley & sons.
Notes
Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2021). Introduction to meta-analysis. John wiley & sons.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explain the basic concepts of systematic review and meta-analysis. |
| LO02 | Formulate a research question and develop an appropriate search strategy. |
| LO03 | Conduct literature searches and apply the study selection process. |
| LO04 | Perform data extraction and quality assessment. |
| LO05 | Explain the basic statistical methods used in meta-analysis. |
| LO06 | Interpret meta-analysis results. |
| LO07 | Report systematic review and meta-analysis findings. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Students comprehends the fundamentals of statistical theory related to the field of health ( probability and bayesian biostatistics). | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Students explain demographic terminologies and statistical methods in the field of health sciences. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Students understand and use medical terminology. | |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Students collect data from research studies, analyze, and make inferences | 2 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Students knows the system of international classification of diseases, obtain and analyze hospital statistics. | |
| PLO06 | Beceriler - Bilişsel, Uygulamalı | Students design scientific research studies in order to give response to the problem arising from health and clinical sciences | 3 |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Students select the appropriate statistical procedure for analysis , apply and make inferences. | 2 |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Students use the necessary statistical packages for analysis, if necessary write and develop software. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Students follow the latest development in medical informatics and employ frequently used tools and methods. | |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Students design health survey, determine the sampling method and conduct the survey | |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Students select and use proper statistical procedure for diagnosis and in making inferences for the data in health and clinical medicine and provide consultance to clinicians in the field. | 3 |
| PLO12 | Yetkinlikler - Öğrenme Yetkinliği | Students develop the ability of critical thinking, make a conclusion with a critical approach to the evidence | 4 |
| PLO13 | Yetkinlikler - Öğrenme Yetkinliği | Students apply analytical procedure to frequently used survival data, multivariate procedure and regression techniques. | 4 |
| PLO14 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Students provide consulting services by using effective communication skills; take part in research teamworks; defend the ethical rules. | |
| PLO15 | Yetkinlikler - Alana Özgü Yetkinlik | Students explain the fundamental terminologies in epidemiology, guide researchers conducting field survey and clinical studies, develop methodologies in determining disease risk factor and disease burden and advise for choosing proper diagnostic test. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to Systematic Review and Basic Concepts | Reading | Öğretim Yöntemleri: Anlatım |
| 2 | Evidence-Based Medicine and Research Questions | Reading | Öğretim Yöntemleri: Anlatım |
| 3 | Literature Search Strategies | Reading | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 4 | Databases and Keyword Use | Reading | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 5 | Study Selection and Inclusion Criteria | Reading | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 6 | Data Extraction Methods | Reading | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 7 | Risk of Bias and Quality Assessment | Reading | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 9 | Introduction to Meta-Analysis and Basic Concepts | Reading | Öğretim Yöntemleri: Anlatım |
| 10 | Effect Size Measures | Reading | Öğretim Yöntemleri: Anlatım |
| 11 | Assessment of Heterogeneity | Reading | Öğretim Yöntemleri: Anlatım |
| 12 | Fixed-Effect and Random-Effects Models | Reading | Öğretim Yöntemleri: Anlatım |
| 13 | Publication Bias and Sensitivity Analysis | Reading | Öğretim Yöntemleri: Anlatım |
| 14 | Forest Plot and Interpretation of Results | Reading | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 15 | PRISMA Guideline and Reporting | Reading | Öğretim Yöntemleri: Anlatım, Alıştırma ve Uygulama |
| 16 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
|
| 17 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 4 | 4 |
| Final Exam | 1 | 4 | 4 |
| Total Workload (Hour) | 106 | ||
| Total Workload / 25 (h) | 4,24 | ||
| ECTS | 4 ECTS | ||