TÜRKÇE
ENGLISH
Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| Code | MİK617 |
| Name | Bacterial Genetics and Molecular Genetic Techniques |
| Term | 2026-2027 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 4-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Belirsiz |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. TOĞRUL NAĞIYEV |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
To provide the knowledge, skills, and competencies necessary to understand the bacterial genome organisation, gene regulation, horizontal gene transfer mechanisms, and principles and applications of modern molecular genetics techniques, and to evaluate genetic approaches in clinical microbiology and biotechnology.
Course Content
This lecture covers the theoretical foundations of bacterial genetic organisation, gene expression, gene transfer mechanisms, and modern molecular genetics techniques. It also focuses on the clinical and research applications of genomics, transcriptomics, and gene editing technologies.
Course Precondition
Not
Resources
1. Klug, W.S., Cummings, M.R. and Spencer, C.A. (2006). Concepts of Genetics. 8th Edition, Pearson Education International, Upper Saddle River, NJ. 2. Snyder, L. and Champness, W. (2013). Molecular Genetics of Bacteria. 5. Edition, ASM Press.
Notes
1. Murray, P.R., Rosenthal, K.S. and Pfaller, M.A. (2009). Medical Microbiology. 6th Edition, Mosby/Elsevier, Philadelphia.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Analyzes bacterial genome organization and gene expression mechanisms at an advanced level. |
| LO02 | Explains the genetic basis and dissemination mechanisms of antimicrobial resistance (particularly Horizontal Gene Transfer) and interprets them in a clinical context. |
| LO03 | Evaluates the genetic regulation of virulence factors and host–pathogen interactions at the molecular level. |
| LO04 | Selects and compares molecular genetic techniques (e.g., Polymerase Chain Reaction, sequencing technologies, CRISPR-Cas System) for appropriate research and diagnostic purposes. |
| LO05 | Analyzes and interprets molecular data (e.g., PCR, NGS) obtained in clinical microbiology laboratories. |
| LO06 | Evaluates infection spread and outbreaks using molecular epidemiology approaches. |
| LO07 | Critically analyzes current scientific literature and develops original research questions. |
| LO08 | Designs a molecular genetics–based research study and presents its findings scientifically. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Having acquired technical skills through laboratory studies, being able to access information, conduct research, plan experiments, solve problems, interpret experimental results, make presentations, develop strategies on microbiology-related issues | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Having received a quality microbiology education at a standard accepted in international platforms, having broadened scientific horizons and being preferred in many sectors related to microbiology, being competent in microbiology | 5 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Isolates infectious agents | 1 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Performs the steps of identifying infectious agents | 1 |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Knowing and applying laboratory methods used in general bacteriology, virology, parasitology, mycology and immunology at theoretical and practical levels | 2 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Being aware of ethical values and problems in the field of microbiology | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Ability to make critical evaluations on published research in the field of microbiology | 5 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Gaining the competence to present a research conducted in the field of microbiology in written, oral and visual form and prepare it for publication | 3 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Having acquired research and career ethics | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Having deepened knowledge on specific subjects studied (thesis study) |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to Bacterial Genetics in Medical Microbiology | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Bacterial Genome and Clinical Significance | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | DNA Replication, Mutation, and Antibiotic Resistance | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Gene Expression and Virulence Regulation | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Translation and Targeted Antibiotics | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Horizontal Gene Transfer and Resistance Spreading | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Mobile Genetic Elements and MDR | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Studying lecture notes | Ölçme Yöntemleri: Sözlü Sınav |
| 9 | Recombination and Adaptation | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Molecular Diagnostics: PCR and Clinical Applications | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Sequencing and Molecular Epidemiology | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Gene Cloning and Recombinant Technologies | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | CRISPR and its Clinical Applications | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Omics Approaches, Metagenomic Diagnosis, Microbiota and Clinical Integration | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Clinical Case Analysis and Student Presentations | Equipment Inspection, Article Reading | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap, Beyin Fırtınası |
| 16 | Term Exams | Studying lecture notes | Ölçme Yöntemleri: Yazılı Sınav, Performans Değerlendirmesi |
| 17 | Term Exams | Studying lecture notes | Ölçme Yöntemleri: Yazılı Sınav, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 15 | 15 |
| Total Workload (Hour) | 151 | ||
| Total Workload / 25 (h) | 6,04 | ||
| ECTS | 6 ECTS | ||