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Information
| Code | BT018 |
| Name | Modern Spectral Analysis Methods |
| Semester | . Semester |
| Duration (T+A) | 3-3 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. Hacı Ali DÖNDAŞ |
Course Goal
Within the scope of this course, it is aimed to teach the theories of modern spectral analysis methods and techniques, their areas of use, and the properties of the devices used in these techniques, and to use them in organic, bioorganic, drug analyzes and elucidation of the structures of bioactive compounds.
Course Content
Infrared (IR) and Raman spectroscopy, Ultraviolet-visible region (UV-Vis) spectroscopy, Nuclear Magnetic Resonance (NMR) spectroscopy and 2D-COSY, DEPT, APT, HETCOR, HMQC and NOE techniques, interpretation of their spectra and their use in building lighting. X-ray spectroscopy (XRD, XRF), Mass spectrometry (MS), Capillary electrophoresis, Combined Spectral Analysis Methods; Gas Chromatography-Mass Spectrometer (GC-MS) and Gas Chromatography-Tandem Mass Spectrometer (GC-MS/MS), Liquid Chromatography-Mass Spectrometer (LC-MS) and Liquid Chromatography-Mass/Mass Spectrometer (LCMS/MS), Inductive Paired Plasma-Mass Spectrometry (ICP-MS, Capillary Electrophoresis -Mass Spectrometer (CE-MS), Other Combined Spectral Analysis Systems, Combined Spectral Analysis Methods in the analysis of pharmaceuticals, bioorganic, biomaterial and bioactive compounds.
Course Precondition
none.
Resources
Lecture notes.
Notes
Fayer M.D. “Ultrafast Infrared and Raman Spectroscopy”. Marcel Dekker Incorporated 2001 2. Kazuo Nakamoto, Infrared and Raman spectra of inorganic and coordination compounds / 1986 3. Symmetry and spectroscopy:an introduction to vibrational and electronic spectroscopy / Daniel C. Harris ; Michael D. Bertolucci 1989 4. Williams H. D., Fleming I. “Spectroscopic methods in organic chemistry”. Fourth Edt. Revised, McGrawHill Book Company, England, 1989. 5. Balcı M. “Nükleer manyetik rezonans Spektroskopisi”. ODTÜ Geliştirme Vakfı Yayıncılık ve İletişim A.Ş. Birinci Baskı, Ankara, 2000. 6. Horst Friebolin Transl. by Jack Becconsall Basic one-and-two-dimensional NMR spectroscopy, 1993. 7. De Hoffmann E., Stoobant V. “Mass Spectroscopy”. Newyork, John wiley& Sons, Second Ed. 2001. 8. Rene E. Van Grieken, Andrzej A. Markowicz, Handbook of X-ray spectrometry: methods and techniques, 1993. 9. Electrophoresis: theory, techniques and biochemical and clinical applications / Anthony T. Andrews 1986 10. Manz, Pamme, N., Lossfidis, Bioanalytical Chemistry, Imperial colege Press, 2003.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows and applies Nuclear Magnetic Resonance (NMR) spectroscopy. |
| LO02 | Knows and applies modern spectral analysis methods and techniques |
| LO03 | Knows and uses NMR techniques such as 2D- COSY, DEPT, APT, HETCOR, HMQC and NOE |
| LO04 | Applies modern spectral analysis methods to elucidate the structures of bioorganic, drug and bioactive compounds. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develop and deepen the current and advanced knowledge in the field with original thought and / or research at the level of expertise based on the qualifications of the graduate and reach the original definitions that will bring innovation to the field. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interdisciplinary interaction of the field; it achieves original results using knowledge requiring expertise in analysis, synthesis and evaluation of new and complex ideas. | 3 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Evaluates, uses and transfers new information in the field with a systematic approach. | |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Makes leadership in environments that require the analysis of original and interdisciplinary problems. | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It extends the limits of knowledge in its field by publishing at least one scientific article in its field in national and / or international refereed journals and / or producing or interpreting an original work. | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | 4 |
| PLO09 | Yetkinlikler - Alana Özgü Yetkinlik | Conducts scientific research in national and international scientific research groups. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision making processes in solving problems encountered in the field. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Infrared (IR) ve Raman spektroskopisi | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Ultraviyole-görünür bölge (UV-Vis) spektroskopisi | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Nükleer Manyetik Rezonans (NMR) spektroskopisi | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | 2D- COSY, DEPT, APT, HETCOR | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | HMQC ve NOE teknikleri | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Spektrumlarının yorumlanması ve yapı aydınlatmada kullanımları | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | X-ışınları spektroskopisi(XRD, XRF) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 9 | Kapiler elektroforez | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Kütle spektrometresi (MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Kombine Spektral Analiz Yöntemleri | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Gaz Kromatografisi-Kütle Spektrometresi (GC-MS), Gaz Kromatografisi-Tandem Kütle Spektrometresi (GC-MS/MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Sıvı Kromatografisi-Kütle Spektrometresi (LC-MS) ve Sıvı Kromatografisi-Kütle /Kütle Spektrometresi (LC-MS/MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | İndüktif Olarak Eşleştirilmiş Plazma - Kütle Spektrometresi (ICP-MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Kapiler Elektroforez -Kütle Spektrometresi (CE-MS) ve Diğer Kombine Spektral Analiz Sistemleri | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
|
| 17 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||