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Information
| Code | BT0094 |
| Name | Animal Models in Biotechnology and Their Physiology |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 4-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
It is aimed to ensure that they have knowledge about model building and experimental design using biotechnological techniques, to convey the concepts of animal use ethics, 3R principles and animal welfare to researchers, and to teach physiological basics about the animal species they will use in their research.
Course Content
Design of animal experiments using biotechnological techniques, experimental design strategies, physiological basics about model organisms, measuring and evaluating physiological parameters, animal behavior, welfare, 3R principles and ethical rules.
Course Precondition
None
Resources
-Animal Biotechnology Models in Discovery and Translation, Ed. Verma A.S, Singh A., 2nd ed., Academic Press, 2020. -Fundamentals of Laboratory Animal Science, Ed. Liu E., Fan J., 1st ed., CRC Press, 2018. -Transgenic Animal Technology, Ed. Pinkert, 3rd ed., Elsevier, 2014. -Related literature
Notes
-Animal Biotechnology Models in Discovery and Translation, Ed. Verma A.S, Singh A., 2nd ed., Academic Press, 2020. -Fundamentals of Laboratory Animal Science, Ed. Liu E., Fan J., 1st ed., CRC Press, 2018. -Transgenic Animal Technology, Ed. Pinkert, 3rd ed., Elsevier, 2014. -Related literature
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Learns the concept of animal model. |
| LO02 | Learns animal models used in biotechnological research. |
| LO03 | Learns the physiology of the animal model that plans to use in research. |
| LO04 | Learns the application of biotechnological methods in animal model production. |
| LO05 | Learns ethical concepts and rules in animal studies. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | 5 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 3 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | |
| PLO04 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | 2 |
| PLO06 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology | |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - Öğrenme Yetkinliği | Knows the ethical rules to be considered while obtaining biotechnological products. | 3 |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Basic concepts of animal models | Related resources, lecture notes and literatures | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Stages in animal experiments | Related resources, lecture notes and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Planning, organization and administration of animal experiments | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay |
| 4 | Standardization in animal experiments | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap, Grup Çalışması, Örnek Olay |
| 5 | Application areas of biotechnological techniques in animals | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay |
| 6 | Genetic sources of various animals and standardization, purification | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Beyin Fırtınası, Örnek Olay |
| 7 | Approaches to generating genetically modified animal lines | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay, Bireysel Çalışma, Proje Temelli Öğrenme |
| 8 | Approaches to generating genetically modified animal lines 2 | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Proje Temelli Öğrenme |
| 9 | Physiological basics of laboratory animals | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Proje Temelli Öğrenme |
| 10 | Physiological basics of the model organisms (laboratory animals) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Alıştırma ve Uygulama, Deney / Laboratuvar |
| 11 | Physiological basics of aquatic animals | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Örnek Olay, Deney / Laboratuvar, Proje Temelli Öğrenme |
| 12 | Physiological basics of farm / large animals | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Deney / Laboratuvar, Problem Çözme, Beyin Fırtınası, Grup Çalışması |
| 13 | Behavior and welfare of the model organisms | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Alıştırma ve Uygulama, Beyin Fırtınası, Benzetim, Örnek Olay |
| 14 | Ethical principles and regulations in animal experiments | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması |
| 15 | R principles and alternative methods | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Beyin Fırtınası, Örnek Olay, Proje Temelli Öğrenme |
| 16 | Alternative models (in silico, in vitro, 3D-4D technologies) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay, Proje Temelli Öğrenme |
| 17 | Final exams | Related resources, lecture notes, and literature | Ölçme Yöntemleri: Performans Değerlendirmesi, Yazılı Sınav, Sözlü Sınav, Ödev, Proje / Tasarım |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 28 | 28 |
| Total Workload (Hour) | 152 | ||
| Total Workload / 25 (h) | 6,08 | ||
| ECTS | 6 ECTS | ||