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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOTECHNOLOGY (MASTER) (WITH THESIS) (INTERDISCIPLINARY) | |
| Code | BT0094 |
| Name | Animal Models in Biotechnology and Their Physiology |
| Term | 2024-2025 Academic Year |
| Term | Spring |
| Duration (T+A) | 4-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Dr. Öğr. Üyesi SİNAN KANDIR
(Bahar)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The aim of this course is to provide knowledge on creating model organisms using biotechnological techniques, experimental design, the physiological characteristics of animal species used in research, ethical principles, the 3R principle, and animal welfare, and to demonstrate their application in scientific research.
Course Content
This course covers the creation of animal models using biotechnological techniques, experimental design strategies, the physiology of model organisms, measurement and evaluation of physiological parameters, animal behavior and welfare, the 3R principle, and ethical regulations.
Course Precondition
N/A
Resources
-Animal Biotechnology Models in Discovery and Translation, Ed. Verma A.S, Singh A., 2nd ed., Academic Press, 2020. -Fundamentals of Laboratory Animal Science, Ed. Liu E., Fan J., 1st ed., CRC Press, 2018. -Transgenic Animal Technology, Ed. Pinkert, 3rd ed., Elsevier, 2014. -Relevant literature
Notes
-Animal Biotechnology Models in Discovery and Translation, Ed. Verma A.S, Singh A., 2nd ed., Academic Press, 2020. -Fundamentals of Laboratory Animal Science, Ed. Liu E., Fan J., 1st ed., CRC Press, 2018. -Transgenic Animal Technology, Ed. Pinkert, 3rd ed., Elsevier, 2014. -Relevant literature
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Defines the concept of animal models. |
| LO02 | Explains animal models used in biotechnological research. |
| LO03 | Evaluates the physiology of animal models used in research. |
| LO04 | Explains the application of biotechnological methods in the development of animal models. |
| LO05 | Evaluates ethical principles and the 3R principle in animal experiments. |
| LO06 | Interprets animal welfare principles and analyzes their application in experiments. |
| LO07 | Measures and interprets physiological parameters of model organisms. |
| LO08 | Compares genetic modification methods and animal modeling processes. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on undergraduate level qualifications, they develop their knowledge at the level of expertise in the same or a different field. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Knows the ethical rules to be considered while obtaining biotechnological products. | 3 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 3 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO06 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | 2 |
| PLO07 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Basic concepts of animal models | Related resources, lecture notes and literatures | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Stages in animal experiments | Related resources, lecture notes and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Planning, organization and administration of animal experiments | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay |
| 4 | Standardization in animal experiments | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap, Grup Çalışması, Örnek Olay |
| 5 | Application areas of biotechnological techniques in animals | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay |
| 6 | Genetic sources of various animals and standardization, purification | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Beyin Fırtınası, Örnek Olay |
| 7 | Approaches to generating genetically modified animal lines | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay, Bireysel Çalışma, Proje Temelli Öğrenme |
| 8 | Approaches to generating genetically modified animal lines 2 | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Proje Temelli Öğrenme |
| 9 | Physiological basics of laboratory animals | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Proje Temelli Öğrenme |
| 10 | Physiological basics of the model organisms (laboratory animals) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Alıştırma ve Uygulama, Deney / Laboratuvar |
| 11 | Physiological basics of aquatic animals | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Örnek Olay, Deney / Laboratuvar, Proje Temelli Öğrenme |
| 12 | Physiological basics of farm / large animals | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Deney / Laboratuvar, Problem Çözme, Beyin Fırtınası, Grup Çalışması |
| 13 | Behavior and welfare of the model organisms | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Alıştırma ve Uygulama, Beyin Fırtınası, Benzetim, Örnek Olay |
| 14 | Ethical principles and regulations in animal experiments | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması |
| 15 | R principles and alternative methods | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Beyin Fırtınası, Örnek Olay, Proje Temelli Öğrenme |
| 16 | Alternative models (in silico, in vitro, 3D-4D technologies) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay, Proje Temelli Öğrenme |
| 17 | Final exams | Related resources, lecture notes, and literature | Ölçme Yöntemleri: Performans Değerlendirmesi, Yazılı Sınav, Sözlü Sınav, Ödev, Proje / Tasarım |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 2 | 6 | 12 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 154 | ||
| Total Workload / 25 (h) | 6,16 | ||
| ECTS | 6 ECTS | ||