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Information
| Code | BT0109 |
| Name | Signal Transmission in Cancer |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
In this course, students understand the mechanism of the cancer cell's biological behavior, the receptors that affect these behaviors, the signals and how the transmission is done.
Course Content
The role of signal transduction in cancer cells at every stage from DNA repair to cell division, and targeting methods of signal transduction pathways in cancer treatments and their use in biotechnology.
Course Precondition
Basic knowledge of Molecular Biology and Genetics
Resources
Textbook of Cell Signaling in Cancer, Yazarlar: Roberts, Jacques Cell Signaling- Principles and Mechanisms. Yazarlar: Wandell Lim, Bruce Mayer, Tony Pawson Cell Signaling Biology – online tool http://www.cellsignallingbiology.co.uk/csb/
Notes
Textbook of Cell Signaling in Cancer, Yazarlar: Roberts, Jacques Cell Signaling- Principles and Mechanisms. Yazarlar: Wandell Lim, Bruce Mayer, Tony Pawson Cell Signaling Biology – online tool http://www.cellsignallingbiology.co.uk/csb/
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Students understand the mechanism of the cancer cell's biological behavior, the receptors, signals, and transmission that influence these behaviors. |
| LO02 | Have information about the role of signal transduction at every stage from DNA repair to cell division. |
| LO03 | Learns the evaluation of scientific research on the subject and the presentation of articles. |
| LO04 | Have information about targeting methods of signal transduction pathways in cancer treatments. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | 5 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 5 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | |
| PLO04 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | |
| PLO06 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | 4 |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology | 4 |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - Öğrenme Yetkinliği | Knows the ethical rules to be considered while obtaining biotechnological products. | |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to growth factor receptors in cancer with a case, Types of receptors – Research papers | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Tartışma |
| 2 | Ideas and research papers on the working principles of tyrosine kinase family receptors | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Tartışma |
| 3 | Opinions and assignments on signal transduction mechanisms of receptors | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Soru-Cevap |
| 4 | Case-based methods of understanding receptor signal transduction disorders | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Soru-Cevap |
| 5 | Ideas and assignments on targeting the signaling pathway | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Tartışma |
| 6 | In the continuation of the case, ideas on differential diagnosis methods and the methods required for the diagnosis of cancer and determination of research assignments | Textbook, reading the lecture notes and power point presentation | Ölçme Yöntemleri: Ödev |
| 7 | Discussing the story of a patient who applied with the complaint of Chest Pain – thoughts on which diseases the patient's pain will develop | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Tartışma |
| 8 | Mid- term | Textbook, reading the lecture notes and power point presentation | Ölçme Yöntemleri: Performans Değerlendirmesi |
| 9 | Opinions on understanding that the patient's disease in the case develops secondary to the disorder of which mechanisms in the cell | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Tartışma |
| 10 | Understanding how carcinogens cause cancer development in Case 1 and research assignments on cancer cell cycle | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Tartışma |
| 11 | Identification of mutations that may disrupt cell cycle control mechanisms in the case and determination of assignments including investigating their differences with normal cells. | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Tartışma |
| 12 | Investigation of cell cycle signaling system based on homework | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Grup Çalışması |
| 13 | Discussions and design assignments on identifying targets to correct patient-detected mutations | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Soru-Cevap |
| 14 | Evaluation of assignments | Textbook, homework | Ölçme Yöntemleri: Ödev |
| 15 | Article reviews | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Tartışma |
| 16 | Student presentations | Textbook, reading the lecture notes and power point presentation | Öğretim Yöntemleri: Bireysel Çalışma |
| 17 | Final Exam | Textbook, reading the lecture notes and power point presentation | Ölçme Yöntemleri: Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 2 | 6 | 12 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 150 | ||
| Total Workload / 25 (h) | 6,00 | ||
| ECTS | 6 ECTS | ||