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Information
| Code | Trans532 |
| Name | Animal Models in Translational Research |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 4-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
It is aimed to convey the physiological basics of various animal species used in translational research, to examine and evaluate their physiological parameters comparatively, to choose the right experimental animal in line with the researcher's needs, to teach standardization in in vivo studies, power analysis, ethical principles and regulations in the use of experimental animals.
Course Content
This course includes; Animal species and their physiological basics used in translational research, measurement and evaluation of fundamental physiological parameters of various animal species, use of biotechnological techniques in animals, ethical concepts and rules in animal studies.
Course Precondition
N/A
Resources
1. Animal Biotechnology Models in Discovery and Translation, Ed. Verma A.S, Singh A., 2nd ed., Academic Press, 2020. 2. Advances in Animal Biotechnology, Singh B., Mal G., Gautam S.K., Mukesh M., 1st ed., Springer, 2019. 3. Fundamentals of Laboratory Animal Science, Ed. Liu E., Fan J., 1st ed., CRC Press, 2018. 4. Principles of Cloning, Ed. Cibelli J., Gurdon J. et al., 2nd ed., Academic Press, 2014. 5. Transgenic Animal Technology, Ed. Pinkert, 3rd ed., Elsevier, 2014. 6. Lecture notes
Notes
Literature Knowledge
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knowledge - Theoretical, Factual: Learns about various animal species used in translational research. |
| LO02 | Knowledge - Theoretical, Factual: Understands the physiology of the animal species to be used in translational research. |
| LO03 | Skills - Cognitive, Applied: Learns how to measure and evaluate basic physiological parameters of different animal species. |
| LO04 | Competencies - Independent Work and Taking Responsibility: Learns the ethical principles and guidelines in animal studies. |
| LO05 | Competencies - Field-Specific Competency: Gains the ability to design animal experiments in translational research. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on undergraduate-level qualifications, he/she has up-to-date knowledge in the field of Translational Medicine and develops and deepens them. | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Conceives the interdisciplinary interaction in which the field is related to translational medicine. | 5 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Knows the information technologies, technical equipment, and field-specific devices and instruments at the level required by the field of Translational Medicine. | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Knows statistics as a tool that is constantly used in studies in the field of Translational Medicine, and uses relevant software effectively. | 2 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Uses of theoretical and practical knowledge within the field at a proficiency level. | 3 |
| PLO06 | Beceriler - Bilişsel, Uygulamalı | Interprets the knowledge about the field by integrating the information gathered from different disciplines and formulates new knowledge. | 5 |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Makes necessary investigations by using tools, devices, and instruments required for knowledge and technologies about translational medicine and related disciplines at an advanced level; develops a new and creative solution (device, method, treatment, drug) for the problems. | 2 |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Solves the problem faced related to the field by using research methods. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Plans and conducts an experimental study. | 5 |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes responsibility and develops new strategic solutions as a team member in order to solve unexpected complex problems faced within the applications in the field, evaluates the results, and applies when necessary. | 4 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Conducts scientific studies in translational medicine and related fields independently or as a team member. | 4 |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Publishes a scientific paper in a national journal or presents it at a scientific meeting. | 5 |
| PLO13 | Yetkinlikler - Öğrenme Yetkinliği | Evaluates knowledge and skills acquired at proficiency level in the field with a critical approach and direct the learning. | 2 |
| PLO14 | Yetkinlikler - Öğrenme Yetkinliği | Applies the principles of advanced professional development and lifelong learning in the field of Translational Medicine. | 1 |
| PLO15 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates current developments and studies within the field to both professional and non-professional groups systematically using written, oral and visual techniques by supporting quantitative and qualitative data. | 3 |
| PLO16 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates and discusses orally, in writing, and visually with peers by using a foreign language at least at a level of European Language Portfolio B2 General Level. | 2 |
| PLO17 | Yetkinlikler - Alana Özgü Yetkinlik | Develops strategy, policy, and implementation plans on the issues related to the field and assess the findings within the frame of quality processes and ethics. | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to animal usage in translational medicine | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Ethical principles in the use of experimental animals (3R, 5R, 7R) and animal welfare | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Laboratory animals (mice, rats) and their usage in translational medicine | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Deney / Laboratuvar |
| 4 | Laboratory animals (guinea pig, rabbit) and their usage in translational medicine | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Deney / Laboratuvar |
| 5 | Large animal models in translational research | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Deney / Laboratuvar |
| 6 | Zebrafish in translational research | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Anlatım, Deney / Laboratuvar |
| 7 | Aquatic animal models used in translational medicine (axolotl, alternative aquatic animals) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Deney / Laboratuvar |
| 8 | Mid-Term Exam | Related resources, lecture notes, and literature | Ölçme Yöntemleri: Ödev, Proje / Tasarım, Performans Değerlendirmesi, Sözlü Sınav |
| 9 | Biotechnological techniques used in animals (reproductive physiology, assisted reproductive techniques, embryo transfer techniques) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Deney / Laboratuvar, Tartışma |
| 10 | Transgenic laboratory animal models | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Deney / Laboratuvar |
| 11 | Transgenic large animal models | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Deney / Laboratuvar |
| 12 | Transgenic aquatic animal models | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Deney / Laboratuvar |
| 13 | Humane Endpoints in experimental animals and necropsy | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Deney / Laboratuvar, Tartışma |
| 14 | Alternative methods (in silico, in vitro, 3D organoids, microphysiological systems) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Deney / Laboratuvar, Tartışma |
| 15 | Design of animal experiments in translational research (choice of the right animal, PREPARE guidelines), standardization, power analysis and biostatistics. | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Deney / Laboratuvar |
| 16 | Term Exams | Related resources, lecture notes, and literature | Ölçme Yöntemleri: Sözlü Sınav, Yazılı Sınav, Performans Değerlendirmesi, Ödev |
| 17 | Term Exams | Related resources, lecture notes, and literature | Ölçme Yöntemleri: Sözlü Sınav, Yazılı Sınav, Performans Değerlendirmesi, Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 5 | 5 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 4 | 4 |
| Final Exam | 1 | 4 | 4 |
| Total Workload (Hour) | 125 | ||
| Total Workload / 25 (h) | 5,00 | ||
| ECTS | 5 ECTS | ||