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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| ZOOTECHNICS (PhD) | |
| Code | ZO684 |
| Name | Epigenetic Mechanisms |
| Term | 2025-2026 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. Mervan BAYRAKTAR |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
Explain epigenetic mechanisms comprehensively from both conceptual and experimental perspectives. Design experiments and analyze data using advanced epigenomic technologies. Interpret epigenetic alterations in the context of animal productivity, health, and environmental adaptation. Integrate epigenomic findings into sustainable livestock practices while evaluating ethical and regulatory dimensions.
Course Content
This doctoral-level course examines molecular epigenetic mechanisms and their impact on animal health, productivity, environmental adaptation, and sustainable breeding strategies. Students gain an in-depth understanding of DNA methylation, histone modifications, chromatin remodeling, nucleosome dynamics, non-coding RNA networks, and their regulatory interactions. Emphasis is placed on cutting-edge epigenomic technologies (WGBS, ChIP-seq, ATAC-seq, Hi-C), bioinformatic workflows, experimental design, critical literature appraisal, and the integration of epigenetic data into livestock-breeding programs. Through laboratory exercises and case studies, participants develop the competence to interpret epigenetic datasets and propose evidence-based improvements for production, health, and welfare.
Course Precondition
Scanning the internet for course-related resources
Resources
Tollefsbol, T. O. (Ed.). (2017). Handbook of epigenetics: the new molecular and medical genetics. Academic Press.
Notes
Tollefsbol, T. O. (Ed.). (2017). Handbook of epigenetics: the new molecular and medical genetics. Academic Press.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explain the functional differences between the genome and epigenome in farm animals. |
| LO02 | Describes the molecular mechanisms of DNA methylation, histone modifications, and chromatin remodeling. |
| LO03 | Analyzes the effects of environmental and nutritional epigenetic changes on animal performance. |
| LO04 | Discusses developmental and transgenerational epigenetic inheritance with case studies. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | After undergraduate education, increases knowledge in one of the fields of animal breeding and breeding, feeds and animal nutrition, biometrics and genetics. | 2 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interaction between different disciplines | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Gains the ability to develop strategic approaches and produce regional, national or international solutions for the field of animal science | 2 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Gains the ability to develop knowledge with scientific methods by using the data in animal science, and to use this knowledge with the awareness of scientific, social and ethical responsibility. | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | Gains the ability to use and develop information technologies with computer software and hardware knowledge required by the field of animal science. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Gains the ability to convey their own studies or current developments in the field of animal science to groups in the field or other fields of science, verbally and visually. | |
| PLO07 | Bilgi - Kuramsal, Olgusal | Gains the ability to evaluate the quality processes of animal products | 2 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Gains the ability to keep animal production dynamic in accordance with changing economic and social conditions. | |
| PLO09 | Bilgi - Kuramsal, Olgusal | Gains the ability to follow national and international current issues, to follow developments in lifelong learning, science and technology, to constantly renew themselves and to transfer innovations to animal production. | |
| PLO10 | Bilgi - Kuramsal, Olgusal | Hayvansal ürünler ile insan sağlığı ve toplum refahı arasındaki ilişkiyi özümser |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to Epigenetics and Historical Perspective | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 2 | DNA Methylation I | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 3 | DNA Methylation II | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 4 | Histone Modifications I | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 5 | Histone Modifications II | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 6 | Chromatin Remodeling & Nucleosome Dynamics | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 7 | Non-Coding RNAs (ncRNAs) & Regulation | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 8 | Mid-Term Exam | Scanning the internet for course-related resources | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev |
| 9 | Environmental & Nutritional Epigenetics | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 10 | Epigenetic Applications in Farm Animals | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 11 | Emerging Technologies for Epigenome Editing | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 12 | Genomic Imprinting & Trans-generational Programming | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 13 | RNA-Based Gene-Silencing Mechanisms | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 14 | İleri DNA Modifikasyonları ve Demetilasyon Dinamikleri | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 15 | Ethics, Regulation & Future Perspectives | Scanning the internet for course-related resources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 16 | Term Exams | Scanning the internet for course-related resources | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev |
| 17 | Term Exams | Scanning the internet for course-related resources | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||