Trans602 DNA Damage and Repair

Genel Bilgi

Dersin Amacı / Hedefi

The learning objective here is for students to gain an understanding of the major DNA repair pathways in eukaryotic cells, highlighting proteins involved in the cellular responses to ionizing radiation or anti-cancer chemotherapy. We will cover the main DNA repair pathways including base excision repair, mismatch repair, nucleotide excision repair, and DNA single strand and double strand break repair. We will stress the mechanisms of non-homologous end joining and homologous recombination repair. The topics of ATM and ATR dependent signaling, H2AX foci and roles of protein phosphorylation and protein ubiquitination, and the relationship of replication stress to the DNA damage response will be covered, as well has human diseases of genomic instability and cancer predisposition.

Dersin İçeriği

DNA repair pathways, highlighting the cellular responses to ionizing radiation will be covered, including: base excision repair, mismatch repair, nucleotide excision repair, and DNA single strand and double strand break repair. The relationship of replication stress to genomic instability in a cancer context will also be covered, as well has human diseases of genomic instability and cancer predisposition.

Dersin Ön Koşulu

Masters level Molecular Biology knowledge is required

Kaynaklar

Notlar

Dersin Öğrenme Çıktıları

Program Öğrenme Çıktıları ile İlişkisi

Haftalık Akış

Öğrenci İş Yükü - AKTS